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Here, we show that mainly excitatory cortical neurons are affected by TDP-43 pathology and define the cell types that are affected the most: intratelencephalic L2-L3-LINC00507-FREM3,...
Here, we show that mainly excitatory cortical neurons are affected by TDP-43 pathology and define the cell types that are affected the most: intratelencephalic L2-L3-LINC00507-FREM3,...
Here, we characterize the cell-type specificity of TDP-43 pathology in the primary ALS/ALS-FTD motor cortex by employing a multi-modal approach that enables highly-resolved identification of cell types.
Cytoplasmic TDP-43 pathology is a pathological sign of ALS/ALS-FTD and a converging disease event across different genotypes, phenotypes and CNS areas. To understand this process and target...
Understanding the Context
In a groundbreaking advance set to redefine our understanding of neurodegenerative disorders, a team of researchers led by Ruf, Khlwein, and Meier has unveiled a multi-modal.
In a groundbreaking advance set to redefine our understanding of neurodegenerative disorders, a team of researchers led by Ruf, Khlwein, and Meier has unveiled a multi-modal.
Here, we show that mainly excitatory cortical neurons are affected by TDP-43 pathology and define the cell types that are affected the most: intratelencephalic L2-L3-LINC00507-FREM3, L3-L5-RORB.
Researchers have developed a multi-modal approach to analyze cell-type specific pathology of TDP-43 in the human motor cortex, offering new insights into neurodegenerative disorders.
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Key Insights
Here, we report a high-resolution, comparative single-cell molecular atlas of the human primary motor and dorsolateral prefrontal cortices and their transcriptional alterations in sporadic and.
Multi-modal dissection of cell-type specific TDP-43 pathology in the motor cortex Single-nucleus multi-omics of the ALS/ALS-FTD motor cortex. Accompanying code repository to Ruf et al..
Researchers identify neuron types most affected by TDP-43 in ALS and FTD. Read the study to explore new clues for targeted therapies.
