Probability of failure at one locus: 1 – 0.1 = 0.9.

Sun, 03 May 2026 14:57:15 +0000

Understanding the Probability of Failure at One Locus: A Key Insight in Genetics and Risk Prediction In the field of genetics and biomedical research, understanding the probability of failure at a single genetic locus is critical for predicting disease risk, developing personalized medicine, and advancing precision health. A fundamental calculation often appears: when a spontaneous mutation occurs at one specific locus, the probability of failure is expressed as 0.9 (or 90%)—meaning the likelihood of successful function is 90%, and the failure probability is 10%. But what does this really mean, and why is it so important? --- ### What Is “Probability of Failure at One Locus”?